Chronic fatigue syndrome (CFS) is a disorder characterized by extreme fatigue or tiredness that doesn’t go away with rest and can’t be explained by an underlying medical condition.
CFS can also be referred to as myalgic encephalomyelitis (ME) or systemic exertion intolerance disease (SEID).
The causes of CFS aren’t fully understood yet. Some theories include viral infection, psychological stress, or a combination of factors.
Because no single cause has been identified, and because many other conditions produce similar symptoms, CFS can be difficult to diagnose.
There are no tests for CFS. Your doctor will have to rule out other causes for your fatigue when determining a diagnosis.
While CFS was previously a controversial diagnosis, it’s now widely accepted as a medical condition.
CFS can affect anyone, though it’s most common among womenTrusted Source in their 40s and 50s. There’s currently no cure, but treatment can relieve symptoms.
Here’s what you need to know about CFS, including symptoms, treatment options, and outlook.
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CFS (Chronic Fatigue Syndrome)
Medically reviewed by Alana Biggers, M.D., MPH — By Stacy Sampson, D.O. on March 12, 2020
Causes
Risk factors
Symptoms
Diagnosis
Treatment
Outlook
Chronic fatigue syndrome (CFS) is a disorder characterized by extreme fatigue or tiredness that doesn’t go away with rest and can’t be explained by an underlying medical condition.
CFS can also be referred to as myalgic encephalomyelitis (ME) or systemic exertion intolerance disease (SEID).
The causes of CFS aren’t fully understood yet. Some theories include viral infection, psychological stress, or a combination of factors.
Because no single cause has been identified, and because many other conditions produce similar symptoms, CFS can be difficult to diagnose.
There are no tests for CFS. Your doctor will have to rule out other causes for your fatigue when determining a diagnosis.
While CFS was previously a controversial diagnosis, it’s now widely accepted as a medical condition.
CFS can affect anyone, though it’s most common among womenTrusted Source in their 40s and 50s. There’s currently no cure, but treatment can relieve symptoms.
Here’s what you need to know about CFS, including symptoms, treatment options, and outlook.
What causes CFS?
The cause of CFS is unknown. Researchers speculate that contributing factors may include:
viruses
a weakened immune system
stress
hormonal imbalances
It’s also possible that some people are genetically predisposed to develop CFS.
Though CFS can sometimes develop after a viral infection, no single type of infection has been found to cause CFS. Some viral infections that have been studied in relation to CFS include those caused by:
Epstein-Barr virus (EBV)
human herpesvirus 6
Ross River virus (RRV)
rubella virus
Infections caused by bacteria, including Coxiella burnetii and Mycoplasma pneumoniae, have also been studied in relation to CFS.
The Centers for Disease Control and Prevention (CDC)Trusted Source has suggested that CFS may be the end stage of multiple different conditions, rather than one specific condition.
In fact, about 1 in 10 peopleTrusted Source with EBV, Ross River virus, or Coxiella burnetii infection will develop a condition that meets the criteria for a CFS diagnosis.
Additionally, researchers say that those who’ve had severe symptoms with any of these three infections are at a higher risk for later developing CFS.
People with CFS sometimes have weakened immune systems, but doctors don’t know whether this is enough to cause the disorder.
People with CFS can also sometimes have abnormal hormone levels. Doctors haven’t yet concluded whether this is significant, either.
Risk factors for CFS
CFS is most commonly seen among people in their 40s and 50s.
Sex also plays an important role in CFS, as women are two to four timesTrusted Source more likely to be diagnosed with CFS than men.
Other factors that may increase your risk for CFS include:
genetic predisposition
allergies
stress
environmental factors
SUBSCRIBE
CFS (Chronic Fatigue Syndrome)
Medically reviewed by Alana Biggers, M.D., MPH — By Stacy Sampson, D.O. on March 12, 2020
Causes
Risk factors
Symptoms
Diagnosis
Treatment
Outlook
Chronic fatigue syndrome (CFS) is a disorder characterized by extreme fatigue or tiredness that doesn’t go away with rest and can’t be explained by an underlying medical condition.
CFS can also be referred to as myalgic encephalomyelitis (ME) or systemic exertion intolerance disease (SEID).
The causes of CFS aren’t fully understood yet. Some theories include viral infection, psychological stress, or a combination of factors.
Because no single cause has been identified, and because many other conditions produce similar symptoms, CFS can be difficult to diagnose.
There are no tests for CFS. Your doctor will have to rule out other causes for your fatigue when determining a diagnosis.
While CFS was previously a controversial diagnosis, it’s now widely accepted as a medical condition.
CFS can affect anyone, though it’s most common among womenTrusted Source in their 40s and 50s. There’s currently no cure, but treatment can relieve symptoms.
Here’s what you need to know about CFS, including symptoms, treatment options, and outlook.
What causes CFS?
The cause of CFS is unknown. Researchers speculate that contributing factors may include:
viruses
a weakened immune system
stress
hormonal imbalances
It’s also possible that some people are genetically predisposed to develop CFS.
Though CFS can sometimes develop after a viral infection, no single type of infection has been found to cause CFS. Some viral infections that have been studied in relation to CFS include those caused by:
Epstein-Barr virus (EBV)
human herpesvirus 6
Ross River virus (RRV)
rubella virus
Infections caused by bacteria, including Coxiella burnetii and Mycoplasma pneumoniae, have also been studied in relation to CFS.
The Centers for Disease Control and Prevention (CDC)Trusted Source has suggested that CFS may be the end stage of multiple different conditions, rather than one specific condition.
In fact, about 1 in 10 peopleTrusted Source with EBV, Ross River virus, or Coxiella burnetii infection will develop a condition that meets the criteria for a CFS diagnosis.
Additionally, researchers say that those who’ve had severe symptoms with any of these three infections are at a higher risk for later developing CFS.
People with CFS sometimes have weakened immune systems, but doctors don’t know whether this is enough to cause the disorder.
People with CFS can also sometimes have abnormal hormone levels. Doctors haven’t yet concluded whether this is significant, either.
Risk factors for CFS
CFS is most commonly seen among people in their 40s and 50s.
Sex also plays an important role in CFS, as women are two to four timesTrusted Source more likely to be diagnosed with CFS than men.
Other factors that may increase your risk for CFS include:
genetic predisposition
allergies
stress
environmental factors
What are the symptoms of CFS?
Symptoms of CFS vary based on the individual and the severity of the condition.
The most common symptom is fatigue that’s severe enough to interfere with your daily activities.
For CFS to be diagnosed, a significantly reduced ability to perform your usual daily activities with fatigue must last for at least 6 months. It must not be curable with bed rest.
You will also experience extreme fatigue after physical or mental activities, which is referred to as post-exertional malaise (PEM). This can last for more than 24 hours after the activity.
CFS can also introduce sleep problems, such as:
feeling unrefreshed after a night’s sleep
chronic insomnia
other sleep disorders
In addition, you may also experience:
loss of memory
reduced concentration
orthostatic intolerance (going from lying or seated to standing positions makes you light-headed, dizzy, or faint)
Physical symptoms of CFS may include:
muscle pain
frequent headaches
multi-joint pain without redness or swelling
frequent sore throat
tender and swollen lymph nodes in your neck and armpits
CFS affects some people in cycles, with periods of feeling worse and then better.
Symptoms may sometimes even disappear completely, which is referred to as remission. However, it’s still possible for symptoms to return later, which is referred to as a relapse.
This cycle of remission and relapse can make it difficult to manage your symptoms, but it’s possible.
How is CFS diagnosed?
CFS is a very challenging condition to diagnose.
According to the Institute of Medicine, as of 2015, CFS occurs in about 836,000 to 2.5 million Americans. It’s estimated, however, that 84 to 91 percent have yet to receive a diagnosis.
There are no medical tests to screen for CFS. Its symptoms are similar to many other conditions. Many people with CFS don’t “look sick,” so doctors may not recognize that they indeed have a health condition.
In order to receive a CFS diagnosis, your doctor will rule out other potential causes and review your medical history with you.
They’ll confirm that you at least have the core symptoms previously mentioned. They’ll also ask about the duration and severity of your unexplained fatigue.
Ruling out other potential causes of your fatigue is a key part of the diagnosis process. Some conditions with symptoms that resemble those of CFS include:
mononucleosis
Lyme disease
multiple sclerosis
lupus (SLE)
hypothyroidism
fibromyalgia
major depressive disorder
severe obesity
sleep disorders
The side effects of certain drugs, such as antihistamines and alcohol, can mimic symptoms of CFS as well.
Because of the similarities between symptoms of CFS and many other conditions, it’s important to not self-diagnose. Talk to your doctor about your symptoms. They can work with you to get relief.
How is CFS treated?
There’s currently no specific cure for CFS.
Each person has different symptoms and therefore may require different types of treatment to manage the disorder and relieve their symptoms.
Work with your team of healthcare providers to create the best treatment plan for you. They can go over the possible benefits and side effects of the therapies with you.
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